Multicomponent Synthesis of 3-Indolepropionic Acids.
β Scribed by Mauro F. A. Adamo; Vivekananda R. Konda
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 29 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Although 3-indolepropionic acid and phenanthridine are achiral molecules, a chiral bimolecular crystal is spontaneously formed; torsional conformation of the propionic acid group plays an important role in the helix formation through hydrogen bonding chain within the crystal lattice.
## Abstract 2βCarboxyphenylpyruvic acid and its derivatives with substituents in the phenyl nucleus can be prepared via a modified azlactone synthesis. These phenylpyruvic acids display a spontaneous ring closure into the corresponding isocoumarin carboxylic acids.