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Multicomponent Synthesis of 3-Heteroarylpropionic Acids.

✍ Scribed by Mauro F. A. Adamo; Eleanor F. Duffy

Publisher
John Wiley and Sons
Year
2007
Weight
32 KB
Volume
38
Category
Article
ISSN
0931-7597

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Synthesis of isocoumarin-3-carboxylic ac
Synthesis of isocoumarin-3-carboxylic acids
✍ C. Ribbens; C. van der Stelt; W. Th. Nauta πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 206 KB

## Abstract 2‐Carboxyphenylpyruvic acid and its derivatives with substituents in the phenyl nucleus can be prepared via a modified azlactone synthesis. These phenylpyruvic acids display a spontaneous ring closure into the corresponding isocoumarin carboxylic acids.