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Synthesis of isocoumarin-3-carboxylic acids

✍ Scribed by C. Ribbens; C. van der Stelt; W. Th. Nauta

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 206 KB
Volume: 79
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19600790108

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✦ Synopsis

Abstract

2‐Carboxyphenylpyruvic acid and its derivatives with substituents in the phenyl nucleus can be prepared via a modified azlactone synthesis. These phenylpyruvic acids display a spontaneous ring closure into the corresponding isocoumarin carboxylic acids.

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