Solid-phase synthesis of substituted ben
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David Tumelty; Matthias K. Schwarz; Kathy Cao; Michael C. Needels
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Article
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1999
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Elsevier Science
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French
⚖ 216 KB
A solid-phase synthesis of benzimidazoles, substituted on the aromatic ring by a variety of groups or atoms, is described. Intermediate 3, derived from the acylation of a resin-bound secondary amine with Fmoc-glycine, was elaborated via nucleophilic displacement with substituted o-halonitroarenes to