MQScore_SNP Software for Multipoint Parametric Linkage Analysis of Quantitative Traits in Large Pedigrees
โ Scribed by Tatiana I. Axenovich; Yurii S. Aulchenko
- Book ID
- 111111551
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 76 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0003-4800
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Goals of this analysis were to map loci contributing to variation in the quantitative trait, Q1, using the lod-score method on data set 1, and to explore the difference in power to map genes when considering the discrete vs. quantitative phenotype. Segregation analyses, after covariate adjustment, c
There are numerous statistical methods for quantitative trait linkage analysis in human studies. An ideal such method would have high power to detect genetic loci contributing to the trait, would be robust to non-normality in the phenotype distribution, would be appropriate for general pedigrees, wo