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Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees

✍ Scribed by Jinko Graham; Nicola H. Chapman; Katrina A.B. Goddard; Ellen L. Goode; Ellen M. Wijsman; Gail P. Jarvik

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
38 KB
Volume
14
Category
Article
ISSN
0741-0395

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✦ Synopsis

Goals of this analysis were to map loci contributing to variation in the quantitative trait, Q1, using the lod-score method on data set 1, and to explore the difference in power to map genes when considering the discrete vs. quantitative phenotype. Segregation analyses, after covariate adjustment, correctly suggested two contributing loci. The major gene on chromosome 5 was successfully mapped, but the major gene on chromosome 8 was not. Comparison of linkage analyses for the qualitative and quantitative traits confirmed that the quantitative trait is more informative, suggesting that localizing disease genes with a qualitative trait would be more difficult in these pedigrees.

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