Exact Multipoint Quantitative-Trait Linkage Analysis in Pedigrees by Variance Components
β Scribed by Stephen C. Pratt; Mark J. Daly; Leonid Kruglyak
- Book ID
- 117853219
- Publisher
- American Society of Human Genetics
- Year
- 2000
- Tongue
- English
- Weight
- 200 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/302830
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π SIMILAR VOLUMES
We investigated the statistical properties of a variance components method for quantitative trait linkage analysis using nuclear families and extended pedigrees.
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## Abstract Variance component linkage analysis is commonly used to map quantitative trait loci (QTLs) in general pedigrees. Large pedigrees are especially attractive for these studies because they provide greater power per genotyped individual than small pedigrees. We propose accurate and computat
## Abstract Two of the major approaches for linkage analysis with quantitative traits in humans include variance components and HasemanβElston regression. Previously, these were viewed as quite separate methods. We describe a general model, fit by use of generalized estimating equations (GEE), for