Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
β Scribed by Laura Almasy; John Blangero
- Book ID
- 117852396
- Publisher
- American Society of Human Genetics
- Year
- 1998
- Tongue
- English
- Weight
- 772 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/301844
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π SIMILAR VOLUMES
We present an overview of pedigree-based variance component linkage methods and discuss their extension to oligogenic inheritance. As an example, oligogenic linkage analyses were performed using the quantitative trait Q4 from the GAW10 simulated data set. A strategy involving sequential oligogenic a
## Abstract Variance component models form a powerful and flexible tool for multipoint linkage analysis of quantitative traits. Estimates of genetic similarity are needed for the variance component model to detect linkage and to locate genes, and two methods are commonly used to calculate multipoin