Monoclonal Antibodies to the Hypervariable Region 1 of Hepatitis C Virus Capture Virus and Inhibit Virus Adsorption to Susceptible Cells in Vitro
β Scribed by Yi-Hua Zhou; Yohko K. Shimizu; Mariko Esumi
- Book ID
- 112272898
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 182 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0042-6822
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## Abstract Hepatitis C virus (HCV) infection may result in acute resolving or chronic infection. Patients that clear the infection have a more vigorous cellular immune response and an early humoral response to the hypervariable region 1 (HVR1) of the E2 envelope protein. To analyse further the pro
To clarify the nature of serum anti-hypervariable region 1 (HVR1) antibodies in patients infected with hepatitis C virus (HCV), we assessed the reactivity of 21 patients' sera with 42 HVR1 proteins by Western blot. HVR1 was expressed as fusion proteins with glutathione S-transferase (GST). The patie