## Abstract Hepatitis C virus (HCV) infection may result in acute resolving or chronic infection. Patients that clear the infection have a more vigorous cellular immune response and an early humoral response to the hypervariable region 1 (HVR1) of the E2 envelope protein. To analyse further the pro
Broadly Cross-Reactive, High-Affinity Antibody to Hypervariable Region 1 of the Hepatitis C Virus in Rabbits
β Scribed by Dazhuang Shang; Wenwu Zhai; Jean-Pierre Allain
- Book ID
- 112272592
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 240 KB
- Volume
- 258
- Category
- Article
- ISSN
- 0042-6822
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π SIMILAR VOLUMES
To clarify the nature of serum anti-hypervariable region 1 (HVR1) antibodies in patients infected with hepatitis C virus (HCV), we assessed the reactivity of 21 patients' sera with 42 HVR1 proteins by Western blot. HVR1 was expressed as fusion proteins with glutathione S-transferase (GST). The patie
## Sequence heterogeneity of hepatitis C virus (HCV) is unevenly distributed along the genome, and maximal variation is confined to a short sequence of the HCV second envelope glycoprotein (E2), designated hypervariable region 1 (HVR1), whose biological function is still undefined. We prospectivel
## Abstract The hypervariable region 1 (HVR1) is the target of neutralizing antibodies but with isolate specificity. The aim of this study was to obtain immunogenic mimotopes of HVR1, which can react broadly with different HVR1 antibodies and could be one of the candidate immunogens in an effective