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Antibodies in Human Sera Specific to Hypervariable Region 1 of Hepatitis C Virus Can Block Viral Attachment

✍ Scribed by Andree Zibert; Eckart Schreier; Michael Roggendorf


Book ID
112270405
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
589 KB
Volume
208
Category
Article
ISSN
0042-6822

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To clarify the nature of serum anti-hypervariable region 1 (HVR1) antibodies in patients infected with hepatitis C virus (HCV), we assessed the reactivity of 21 patients' sera with 42 HVR1 proteins by Western blot. HVR1 was expressed as fusion proteins with glutathione S-transferase (GST). The patie