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Mono N-arylation of piperazine(III): metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate

✍ Scribed by Michael Hepperle; Jeffrey Eckert; Dinesh Gala; Lan Shen; C Anderson Evans; Andrew Goodman

Book ID: 104250975
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 121 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00556-7

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✦ Synopsis

A novel application of Pd 0 -catalyzed arylation to mono N-arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N,N%-diarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N%-(4-aminophenyl)piperazine 5 as well as posaconazole 1 are described.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v