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Sequential mono-N-arylation of piperazine nitrogens. Part 1: A simplified method and its application to the preparation of a key N,N′-biaryl piperazine antifungal intermediate

✍ Scribed by Michael Hepperle; Jeffrey Eckert; Dinesh Gala


Book ID
104261886
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
292 KB
Volume
40
Category
Article
ISSN
0040-4039

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A novel application of Pd 0 -catalyzed arylation to mono N-arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N,N%-diarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N%-(4-aminophenyl)piperazine 5 as well as posaconazole 1 ar