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Copper-Catalyzed N-Arylation/Hydroamin(d)ation Domino Synthesis of Indoles and its Application to the Preparation of a Chek1/KDR Kinase Inhibitor Pharmacophore

✍ Scribed by Lutz Ackermann; Sebastian Barfüßer; Harish K. Potukuchi

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 256 KB
Volume: 351
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200900004

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✦ Synopsis

Abstract

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Inexpensive copper catalysts allow for efficient syntheses of N‐aryl‐, N‐acyl‐, or N‐H‐(aza)indoles starting from ortho‐alkynylbromoarenes. The broad scope of this domino N‐arylation/hydroamin(d)ation process is highlighted by the synthesis of highly functionalized indoles, as well as of a Chek1/KDR inhibitor pharmacophore.

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ChemInform Abstract: Copper-Catalyzed N-

ChemInform Abstract: Copper-Catalyzed N-Arylation/Hydroamin(d)ation Domino Synthesis of Indoles and Its Application to the Preparation of a Chek1/KDR Kinase Inhibitor Pharmacophore.

✍ Lutz Ackermann; Sebastian Barfuesser; Harish K. Potukuchi 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

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