Monday afternoon grand ballroom F papers 181–188. Clinical imaging: Knee

✍ Scribed by KP Schellhas; JV Crues III

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 411 KB
• Volume: 1
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880010236

✦ Synopsis

been previously described in HC was a focal flattening of the dorsal surface and thinning of the posterior body of the corpus callosum (CC). All but 3 of the 24 individuals who demonstrated this phenomenon exhibited imbalance, gait disturbance. memory deficits, and/or incontinence. In the absence of this specific CC abnormality, only 1 of the remaining 16 subjects exhibited such symptoms. The structure responsible for focal callosal flattening and thinning is the rigid free surface of the falx cerebri as it impinges on the caudal extent of the upwardly expanding CC in HC. This mechanical insult results in incomplete. progressive axonal dysfunction corresponding to a partial dynamic hemispheric disconnection. It is proposed that this dysfunction defines a callosal and possibly a hippocampal commissuropathy that is represented by aberrant action potentials actively radiating outwardly to the cerebral cortex and subcortical gray matter bihemispherically. It is suggested that this commissuropathy accounts, in part, for the complex clinical syndrome manifested by subjects with HC.