✦ LIBER ✦

Molecules involved in cell death and peripheral tolerance

✍ Scribed by Jin Wang; Michael J Lenardo

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 863 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80184-7

No coin nor oath required. For personal study only.

✦ Synopsis

Apoptosis is important for maintaining peripheral lymphocyte homeostasis and for minimizing the accumulation of autoreactive lymphocytes. Disruption of apoptotic pathways has been linked to lymphadenopathy, breakdown of peripheral tolerance and the development of autoimmune diseases. Major progress has been made during the past year in understanding the critical roles of a variety of signaling moleoules, especially a group of cysteine proteases, for the execution of apoptosis. These proteases appear to be the primary effector molecules responsible for carrying out lymphocyte apoptosis and may be critical for peripheral immunological tolerance.

📜 SIMILAR VOLUMES

CD4+ T-cell subsets and cytokines involv

CD4+ T-cell subsets and cytokines involved in peripheral tolerance

✍ William O. Weigle; Carole G. Romball 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 464 KB

Peripheral tolerance is induced under conditions that avoid activation of antigen-presenting cells (APCs) to release cytokines. Such tolerance occurs in both CD4+ T helper (Th)-cell subsets (Th1 and Th2), probably because it is induced in precursor cells. By contrast, activation of APCs to release c

Molecules involved in T-cell costimulati

Molecules involved in T-cell costimulation

✍ Marc K. Jenkins; Julia G. Johnson 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 912 KB

Molecules involved in cell-cell adhesion

Molecules involved in cell-cell adhesion during development

✍ Edelman, Gerald M. ;Rutishauser, Urs 📂 Article 📅 1981 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 731 KB

Over the past decade there have been many attempts to identify the molecules that serve as ligands in cell-cell adhesion. In general, these studies have focused on a search for substances endogenous to a tissue that can either enhance or inhibit aggregation directly and that either demonstrate tissu

Cell-surface molecules involved in T-cel

Cell-surface molecules involved in T-cell functions

✍ Jeffrey A Bluestone; Richard J Hodes 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 461 KB

Involvement of the Fas (CD95) system in

Involvement of the Fas (CD95) system in peripheral cell death and lymphoid organ development

✍ Yasmina Laouar; Adelaida Sarukhan; Valérie Pasqualetto; Corinne Garcia; Sophie E 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 2 views

Fas-mediated apoptosis is a form of cell death that operates through a Fas-Fas ligand (FasL) interaction. In this study we investigated the role of the Fas system during development of normal and Fas-mutated lymphocytes. Irradiated RAG2 -/-recipients were reconstituted with bone marrow cells from B6

Identification of genes involved in prog

Identification of genes involved in programmed cell death

✍ Gregory P. Owens; J. John Cohen 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 711 KB

Three modes of activation of apoptosis are described: induction, in which new gene expression occurs after the stimulus is applied; transduction, in which gene expression is unnecessary at the time of stimulation; and release, in which apoptosis is activated by the inhibition of gene expression. Gen