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CD4+ T-cell subsets and cytokines involved in peripheral tolerance

✍ Scribed by William O. Weigle; Carole G. Romball

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 464 KB
Volume: 18
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(97)01151-1

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✦ Synopsis

Peripheral tolerance is induced under conditions that avoid activation of antigen-presenting cells (APCs) to release cytokines. Such tolerance occurs in both CD4+ T helper (Th)-cell subsets (Th1 and Th2), probably because it is induced in precursor cells. By contrast, activation of APCs to release cytokines by immunization or infection activates either both subsets or predominantly one of them. A model for CD4+ T-cell tolerization and subset expansion is presented here.

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