The discovery of human cells expressing TCRy6, the genes which encode it and the TCRyS proteins which are expressed
Activated CD4+and CD8+T-cell subsets in Wegener's granulomatosis
β Scribed by M. Schlesier; T. Kaspar; J. Gutfleisch; G. Wolff-Vorbeck; H. -H. Peter
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 704 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0172-8172
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## Abstract ## Objective Accumulating data support the role of regulatory T cells, a subset of CD4+ T cells that expresses CD25^high^ and the transcription factor forkhead box P3 (FoxP3), in controlling and preventing autoimmunity. In Wegener's granulomatosis (WG), an autoimmune vasculitis, upβreg
CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta
Distinct y/6 T cell receptors define