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Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

✍ Scribed by A. Siddiqui; T. Lacroix; M. R. Stasko; J. J. Scott-McKean; A. C. S. Costa; K. J. Gardiner

Book ID
111273229
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
476 KB
Volume
7
Category
Article
ISSN
1601-1848

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Down syndrome mouse models Ts65Dn, Ts1Cj
Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes
✍ L.E. Olson; R.J. Roper; L.L. Baxter; E.J. Carlson; C.J. Epstein; R.H. Reeves πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 296 KB

## Abstract Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn mouse carries a small chromosome derived primarily from mouse chromosome 16, causing dosage imbalance for approximately half of human chromosome 21 orthologs. These mice have cerebellar pathology with direct pa