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Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome

โœ Scribed by Aarti Ruparelia; Matthew L Pearn; William C Mobley


Book ID
119221212
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
265 KB
Volume
22
Category
Article
ISSN
0959-4388

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Down syndrome mouse models Ts65Dn, Ts1Cj
โœ L.E. Olson; R.J. Roper; L.L. Baxter; E.J. Carlson; C.J. Epstein; R.H. Reeves ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 296 KB

## Abstract Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn mouse carries a small chromosome derived primarily from mouse chromosome 16, causing dosage imbalance for approximately half of human chromosome 21 orthologs. These mice have cerebellar pathology with direct pa