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Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome

✍ Scribed by Pavel V. Belichenko; Eliezer Masliah; Alexander M. Kleschevnikov; Angela J. Villar; Charles J. Epstein; Ahmad Salehi; William C. Mobley


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
992 KB
Volume
480
Category
Article
ISSN
0021-9967

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## Abstract Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn mouse carries a small chromosome derived primarily from mouse chromosome 16, causing dosage imbalance for approximately half of human chromosome 21 orthologs. These mice have cerebellar pathology with direct pa

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Ts65Dn mice are a genetic model for Down syndrome. Both individuals with Down syndrome and Ts65Dn mice have reduced cerebellar volumes and the cerebellum is involved in motor learning. ConΒ―icting results have been reported on the motor learning abilities of Ts65Dn mice, which may be related to proce

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Mouse genetic models can be used to dissect molecular mechanisms that result in human disease. This approach requires detection and demonstration of compelling parallels between phenotypes in mouse and human. Ts65Dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or