Ts65Dn mice are a genetic model for Down syndrome. Both individuals with Down syndrome and Ts65Dn mice have reduced cerebellar volumes and the cerebellum is involved in motor learning. Conยฏicting results have been reported on the motor learning abilities of Ts65Dn mice, which may be related to proce
Erratum: Motor learning in Ts65Dn mice, a model for Down Syndrome
โ Scribed by Lynn A. Hyde; Linda S. Crnic; Amber Pollock; Paula C. Bickford
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 44 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0012-1630
- DOI
- 10.1002/dev.1014
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Mouse genetic models can be used to dissect molecular mechanisms that result in human disease. This approach requires detection and demonstration of compelling parallels between phenotypes in mouse and human. Ts65Dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or
## Abstract Agonistโ and guanineโnucleotideโstimulated phospholipase Cโฮฒ (PLC) activity was characterized in crude plasma membrane preparations from cerebral cortex, hippocampus and cerebellum of Ts65Dn mice, a model for Down syndrome, and their control littermates. The levels of expression of PLCโ