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Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome

✍ Scribed by Joshua D. Blazek; Cherie N. Billingsley; Abby Newbauer; Randall J. Roper

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 260 KB
Volume: 239
Category: Article
ISSN: 1058-8388
DOI: 10.1002/dvdy.22295

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## Abstract Agonist‐ and guanine‐nucleotide‐stimulated phospholipase C‐β (PLC) activity was characterized in crude plasma membrane preparations from cerebral cortex, hippocampus and cerebellum of Ts65Dn mice, a model for Down syndrome, and their control littermates. The levels of expression of PLC‐