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Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

✍ Scribed by Arnaud Duchon; Matthieu Raveau; Claire Chevalier; Valérie Nalesso; Andrew J. Sharp; Yann Herault


Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
773 KB
Volume
22
Category
Article
ISSN
0938-8990

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Down syndrome mouse models Ts65Dn, Ts1Cj
✍ L.E. Olson; R.J. Roper; L.L. Baxter; E.J. Carlson; C.J. Epstein; R.H. Reeves 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 296 KB

## Abstract Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn mouse carries a small chromosome derived primarily from mouse chromosome 16, causing dosage imbalance for approximately half of human chromosome 21 orthologs. These mice have cerebellar pathology with direct pa