Down syndrome mouse models Ts65Dn, Ts1Cj
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L.E. Olson; R.J. Roper; L.L. Baxter; E.J. Carlson; C.J. Epstein; R.H. Reeves
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Article
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2004
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John Wiley and Sons
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English
⚖ 296 KB
## Abstract Two mouse models are widely used for Down syndrome (DS) research. The Ts65Dn mouse carries a small chromosome derived primarily from mouse chromosome 16, causing dosage imbalance for approximately half of human chromosome 21 orthologs. These mice have cerebellar pathology with direct pa