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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

โœ Scribed by Ayton, Paul M; Cleary, Michael L

Book ID
110065892
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
435 KB
Volume
20
Category
Article
ISSN
0950-9232

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The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal translocations associated with human acute leukemias. These translocations result in a gain of MLL function by generating novel chimeric proteins containing the amino-terminus of MLL fused inframe with one of 30 distinct partne

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The AML1/EVI-1 chimeric gene is generated by the t(3;21)(q26;q22) translocation and plays a pivotal role in progression of hematopoietic stem cell malignancies such as chronic myelocytic leukemia and myelodysplastic syndrome. In AML1/EVI-1, an N-terminal half of AML1 including a runt homology domain