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Molecular mechanisms of protein-mediated membrane fusion

✍ Scribed by Frederick M Hughson

Book ID
116166002
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
924 KB
Volume
5
Category
Article
ISSN
0959-440X

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The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal translocations associated with human acute leukemias. These translocations result in a gain of MLL function by generating novel chimeric proteins containing the amino-terminus of MLL fused inframe with one of 30 distinct partne