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Mechanisms of leukemogenesis by MLL fusion proteins

✍ Scribed by Rolf Marschalek

Book ID
108677042
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
575 KB
Volume
152
Category
Article
ISSN
0007-1048

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Molecular mechanisms of leukemogenesis m
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
✍ Ayton, Paul M; Cleary, Michael L πŸ“‚ Article πŸ“… 2001 πŸ› Nature Publishing Group 🌐 English βš– 435 KB

The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal translocations associated with human acute leukemias. These translocations result in a gain of MLL function by generating novel chimeric proteins containing the amino-terminus of MLL fused inframe with one of 30 distinct partne