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Dimerization of MLL fusion proteins immortalizes hematopoietic cells

โœ Scribed by Mary Ellen Martin; Thomas A Milne; Sebastien Bloyer; Karine Galoian; Weiping Shen; Denise Gibbs; Hugh W Brock; Robert Slany; Jay L Hess

Book ID
114413340
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
568 KB
Volume
4
Category
Article
ISSN
1535-6108

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โœ Ayton, Paul M; Cleary, Michael L ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 435 KB

The MLL (Mixed Lineage Leukemia) gene is a common target for chromosomal translocations associated with human acute leukemias. These translocations result in a gain of MLL function by generating novel chimeric proteins containing the amino-terminus of MLL fused inframe with one of 30 distinct partne