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Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines

✍ Scribed by B Buecher; A Broquet; D Bouancheau; M.-F Heymann; A Jarry; M.G Denis; C Bonnet; J.-P Galmiche; H.M Blottière

Book ID: 119631605
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 362 KB
Volume: 35
Category: Article
ISSN: 1590-8658
DOI: 10.1016/s1590-8658(03)00272-x

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## Abstract ## Background. The protooncogenes Ets‐1 and Ets‐2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets‐1 and Ets‐2 synthesis in