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The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines

✍ Scribed by Wolfgang Lamm; Laurenz Vormittag; Dritan Turhani; Boban M. Erovic; Cornelia Czembirek; Christina Eder-Czembirek; Dietmar Thurnher

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
215 KB
Volume
27
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

The protooncogenes Ets‐1 and Ets‐2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets‐1 and Ets‐2 synthesis in head and neck tumors.

Methods.

Expression of Ets‐1 and Ets‐2 was analyzed in tumor tissues by immunohistochemistry. The influence of nimesulide and an extracellular signal‐regulated kinase (ERK) inhibitor on cell proliferation of two head and neck cancer cell lines and Ets‐1 and Ets‐2 expression was determined by automated cell counting and Western blotting, respectively.

Results.

Immunohistochemistry showed a high expression of Ets‐1 and Ets‐2 in tumor tissues. In both cell lines, Ets‐1 and Ets‐2 expression were reduced after 24 and 48 hours by nimesulide.

Conclusion.

Both Ets‐1 and Ets‐2 are overexpressed in head and neck cancer specimens. Inhibition of Ets‐1 and Ets‐2 expression in head and neck cancer cell lines by nimesulide might explain the proapoptotic property of this COX‐2 inhibitor. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005

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