## Abstract Cyclooxygenase 2 (COXβ2) has been suggested to be associated with liver carcinogenesis. Several reports have shown that NSAIDs inhibit the growth of hepatocellular carcinoma cell lines. There is little evidence of how COXβ2 inhibitors regulate the proliferation of hepatocellular carcino
Study on the expression of cyclooxygenase-2 in hepatocellular carcinoma cell lines and on the growth inhibition effect of NS-398
β Scribed by Kun Wang; Bao-cai Xing; Qing-yun Zhang; Guang-wei Xu
- Book ID
- 107466794
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2006
- Tongue
- English
- Weight
- 797 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1000-9604
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Hepatocyte growth factor (HGF), identical to scatter factor, (SF) is a secretory glycoprotein from fibroblasts which dissociates and increases the motility of various types of epithelial cells. After treatment of three gastric carcinoma cell lines (MKN-28, MKN-45 and TMK-1) with HGF (10 ng/ml), TMK-
## Abstract ## Background. Although cyclooxygenaseβ2 (COXβ2) has been suggested to play an important role in carcinogenesis, the effects of tumor suppressors on COXβ2 gene expression and the combined antitumor effects of tumor suppressors and COXβ2 inhibitors have rarely been investigated. ## Met