Classical lissencephaly (LIS) and subcortical band heterotopia (SBH) are related cortical malformations secondary to abnormal migration of neurons during early brain development. Approximately 60% of patients with classical LIS, and one patient with atypical SBH have been found to have deletions or
✦ LIBER ✦
Molecular analysis of the lissencephaly gene 1 (LIS-1) in medulloblastomas
✍ Scribed by A. Koch; J. Tonnt; J. A. Kraus; N. Sörensen; S. Albrecht; O. D. Wiestler; T. Pietsch
- Book ID
- 115083635
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 969 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0305-1846
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## Abstract Our group has previously demonstrated a high frequency of allelic loss on the short arm of chromosome 8 and identified a region of homozygous deletion of 1.41 Mb, flanked by D8S520 and D8S1130, on 8p23.1 in medulloblastomas, suggesting the presence of a tumor suppressor gene in this cri
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