A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function
β Scribed by Vallee, Richard B.; Faulkner, Nicole E.; Dujardin, Denis L.; Tai, Chin-Yin; Vaughan, Kevin T.; O'Connell, Christopher B.; Wang, Yu-li
- Book ID
- 118674969
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 611 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1465-7392
- DOI
- 10.1038/35041020
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Classical lissencephaly (LIS) and subcortical band heterotopia (SBH) are related cortical malformations secondary to abnormal migration of neurons during early brain development. Approximately 60% of patients with classical LIS, and one patient with atypical SBH have been found to have deletions or
## Abstract Normal human somatic cells, unlike cancer cells, stop dividing after a limited number of cell divisions through the process termed cellular senescence or replicative senescence, which functions as a tumorβsuppressive mechanism and may be related to organismal aging. By means of the cDNA