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Molecular analysis of secondary kinase mutations in imatinib-resistant gastrointestinal stromal tumors

โœ Scribed by Ken-Hong Lim; Ming-Jer Huang; Li-Tzong Chen; Tsang-En Wang; Chien-Liang Liu; Cheng-Shyong Chang; Mei-Chin Liu; Reuy-Kuen Hsieh; Chin-Yuan Tzen

Book ID
107576646
Publisher
Springer US
Year
2007
Tongue
English
Weight
194 KB
Volume
25
Category
Article
ISSN
1357-0560

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## Abstract __BRAF__ and __NRAS__ are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was shown to overexpress KIT and harbor __KIT__ mutations. Although most gastrointestinal stromal tumors (GISTs) exhibit activa