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Mechanisms of resistance to imatinib and sunitinib in gastrointestinal stromal tumor

โœ Scribed by Wei-Lien Wang; Anthony Conley; David Reynoso; Laura Nolden; Alexander J. Lazar; Suzanne George; Jonathan C. Trent

Publisher
Springer
Year
2010
Tongue
English
Weight
384 KB
Volume
67
Category
Article
ISSN
0344-5704

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## Abstract __BRAF__ and __NRAS__ are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was shown to overexpress KIT and harbor __KIT__ mutations. Although most gastrointestinal stromal tumors (GISTs) exhibit activa