## Abstract Although surgery remains the mainstay for the treatment of primary gastrointestinal stromal tumors (GIST), a significant number of patients experience disease recurrence within 5 years of surgery. The emergence of imatinib therapy for the treatment of patients with advanced GIST has off
β¦ LIBER β¦
The role of imatinib plasma level testing in gastrointestinal stromal tumor
β Scribed by Suzanne George; Jonathan C. Trent
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 224 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0344-5704
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## Abstract Mutations of protoβoncogene cβKIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs because of its inhibitory effect on KIT kinase activity. To investigate t