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Sunitinib-resistant gastrointestinal stromal tumors harborcis-mutations in the activation loop of theKITgene

✍ Scribed by Toshirou Nishida; Tsuyoshi Takahashi; Akiko Nishitani; Toshihiko Doi; Kuniaki Shirao; Yoshito Komatsu; Kiyokazu Nakajima; Seiichi Hirota; Japanese Study Group on GIST


Publisher
Springer
Year
2009
Tongue
English
Weight
451 KB
Volume
14
Category
Article
ISSN
1341-9625

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## Abstract ## Background and objective to analyze the frequency and spectrum of KIT and platelet‐derived growth factor receptor‐alpha (PDGFRA) gene in a large series of study and to explore the clinical implication of mutations in the gastrointestinal stromal tumors (GISTs) in China. ## Method