Deletions of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic changes in neuroblastoma cells. Technical difficulties in cytogenetic analysis of this tumour have hampered the recognition of other recurring abnormalities, but recent use of molecular cytogenetic tech
Molecular analysis of chromosome arm 17q gain in neuroblastoma
✍ Scribed by Isabelle Janoueix-Lerosey; Dominique Penther; Martine Thioux; Patricia de Crémoux; Josette Derré; Peter Ambros; Philippe Vielh; Jean Bénard; Alain Aurias; Olivier Delattre
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 182 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1045-2257
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It has recently been recognized that unbalanced translocations resulting in the gain of material from 17q are the most common chromosomal changes in neuroblastoma. These rearrangements are associated with established indicators of bad prognosis and poor patient survival. We have used 13 fluorescence
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