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Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma

✍ Scribed by Marco Theobald; Holger Christiansen; Anke Schmidt; Badrig Melekian; Nicole Wolkewitz; Nina M. Christiansen; Christian Brinkschmidt; Frank Berthold; Fritz Lampert

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 177 KB
Volume: 26
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199909)26:1<40::aid-gcc6>3.0.co;2-w

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✦ Synopsis

RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma.

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