## Background: We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines. ## Procedure: The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately
Comprehensive analysis of chromosome 1p deletions in neuroblastoma
โ Scribed by Maris, John M. ;Guo, Chun ;Blake, David ;White, Peter S. ;Hogarty, Michael D. ;Thompson, Patricia M. ;Rajalingam, Vasanthi ;Gerbing, Robert ;Stram, Daniel O. ;Matthay, Katherine K. ;Seeger, Robert C. ;Brodeur, Garrett M.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 190 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0098-1532
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Background. Deletion of the distal short arm of chromosome 1 occurs in 25-35% of primary neuroblastomas, and a putative tumor suppressor gene has been mapped to a consensus region of deletion at 1p36.2-36.3. Indirect evidence suggests the presence of an imprinted neuroblastoma suppressor gene within