Background. Deletion of the distal short arm of chromosome 1 occurs in 25-35% of primary neuroblastomas, and a putative tumor suppressor gene has been mapped to a consensus region of deletion at 1p36.2-36.3. Indirect evidence suggests the presence of an imprinted neuroblastoma suppressor gene within
Detailed molecular analysis of 1p36 in neuroblastoma
โ Scribed by White, P.S. ;Thompson, P.M. ;Seifried, B.A. ;Sulman, E.P. ;Jensen, S.J. ;Guo, C. ;Maris, J.M. ;Hogarty, M.D. ;Allen, C. ;Biegel, J.A. ;Matise, T.C. ;Gregory, S.G. ;Reynolds, C.P. ;Brodeur, G.M.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 204 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0098-1532
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Background. Human p73, a novel homolog of p53, has recently been cloned and mapped at chromosome 1p36.3, the locus for putative tumor suppressor gene(s) of neuroblastoma (NBL) and other cancers. p73, like p53, inhibits growth and induces apoptosis in neuroblastoma and osteosarcoma cell lines. Proced