Several vitamin A compounds have been tested for their ability to suppress formation of DNA adduct by the carcinogen benzo[alpyrene (B[a]P) in an in vitro reaction catalyzed by rat liver microsomes. Retinol, retinal, 3-dehydroretinol and 3-hydroxyretinol were found to be effective inhibitors of addu
β¦ LIBER β¦
Modulation by plant flavonoids and related phenolics of microsome catalyzed adduct formation between benzo[a]Pyrene and DNA
β Scribed by G.M. Shah; R.K. Bhattacharya
- Book ID
- 114009351
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 1016 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-2797
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## Abstract We demonstrate in cell culture that mammary epithelial cells from normal human breast specimens metabolize benzo(a)pyrene (BaP) and form adducts with the bases of their DNA more readily and at lower concentrations of BaP than do fibroblasts from the same specimens. BaP metabolism and ad