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Modular strategy for the synthesis of functionalized aryl-fused azabicyclo[2.2.2]octanes via radical-mediated cascade cyclization

โœ Scribed by Malinakova, Helena C.; Raikar, Sandeep N.; McCormick, Lucas F.


Book ID
122258391
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
633 KB
Volume
55
Category
Article
ISSN
0040-4039

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A highly efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system was developed. The new iterative method involves SmI2-induced reductive intramolecular cyclization of an aldehyde and a [~-alkoxy acrylate as the key step, producing a 2,3-trans-tetrahydropyran r