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An efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system via SmI2-induced reductive intramolecular cyclization

โœ Scribed by Nobuyuki Hori; Hiroko Matsukura; Goh Matsuo; Tadashi Nakata

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
259 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A highly efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system was developed. The new iterative method involves SmI2-induced reductive intramolecular cyclization of an aldehyde and a [~-alkoxy acrylate as the key step, producing a 2,3-trans-tetrahydropyran ring.

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