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Modular Solid-Phase Synthesis of Teroxazoles as a Class of α-Helix Mimetics

✍ Scribed by Cristiano Pinto Gomes; Alexander Metz; Jan W. Bats; Holger Gohlke; Michael W. Göbel


Book ID
112082887
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
830 KB
Volume
2012
Category
Article
ISSN
1434-193X

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✍ Lionel Moisan; Severin Odermatt; Naran Gombosuren; Alexandre Carella; Julius Reb 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 1 views

## Abstract The synthesis of nonpeptidic α‐helix mimetics based on a tricyclic oxazole–pyrrole–piperazine scaffold is described. The scaffold presents both a hydrophobic surface for recognition and a hydrophilic edge that enhances solubility. The synthesis is highly modular and allows the targeting