Synthesis of an Oxazole–Pyrrole–Piperazine Scaffold as an α-Helix Mimetic

✍ Scribed by Lionel Moisan; Severin Odermatt; Naran Gombosuren; Alexandre Carella; Julius Rebek Jr.

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 169 KB
• Volume: 2008
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200701164

✦ Synopsis

Abstract

The synthesis of nonpeptidic α‐helix mimetics based on a tricyclic oxazole–pyrrole–piperazine scaffold is described. The scaffold presents both a hydrophobic surface for recognition and a hydrophilic edge that enhances solubility. The synthesis is highly modular and allows the targeting of a range of protein–protein interactions involving α‐helices. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)