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Design, Synthesis, and Conformational Analysis of Trispyrimidonamides as α-Helix Mimetics

✍ Scribed by Spanier, Lukas; Ciglia, Emanuele; Hansen, Finn K.; Kuna, Krystina; Frank, Walter; Gohlke, Holger; Kurz, Thomas


Book ID
124057390
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
613 KB
Volume
79
Category
Article
ISSN
0022-3263

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## Abstract The synthesis of nonpeptidic α‐helix mimetics based on a tricyclic oxazole–pyrrole–piperazine scaffold is described. The scaffold presents both a hydrophobic surface for recognition and a hydrophilic edge that enhances solubility. The synthesis is highly modular and allows the targeting