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Synthesis of a 2,3‘;6‘,3‘ ‘-Terpyridine Scaffold as an α-Helix Mimetic

✍ Scribed by Davis, Jessica M.; Truong, Anh; Hamilton, Andrew D.


Book ID
115509183
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
131 KB
Volume
7
Category
Article
ISSN
1523-7060

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## Abstract The synthesis of nonpeptidic α‐helix mimetics based on a tricyclic oxazole–pyrrole–piperazine scaffold is described. The scaffold presents both a hydrophobic surface for recognition and a hydrophilic edge that enhances solubility. The synthesis is highly modular and allows the targeting