Synthesis of an Oxazole–Pyrrole–Piperazi
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Lionel Moisan; Severin Odermatt; Naran Gombosuren; Alexandre Carella; Julius Reb
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Article
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2008
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John Wiley and Sons
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English
⚖ 169 KB
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## Abstract The synthesis of nonpeptidic α‐helix mimetics based on a tricyclic oxazole–pyrrole–piperazine scaffold is described. The scaffold presents both a hydrophobic surface for recognition and a hydrophilic edge that enhances solubility. The synthesis is highly modular and allows the targeting