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Modular Nucleic Acid Surrogates. Solid Phase Synthesis of α-Helical Peptide Nucleic Acids (αPNAs)

✍ Scribed by Garner, Philip; Dey, Subhakar; Huang, Yumei; Zhang, Xiao


Book ID
127320197
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
76 KB
Volume
1
Category
Article
ISSN
1523-7060

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Solid-Phase synthesis of peptide nucleic
✍ Dr. Leif Christensen; Richard Fitzpatrick; Brian Gildea; Kenneth H. Petersen; He 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB

Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA