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Modular amino acids-based chiral ligands for copper-catalyzed enantioselective conjugation addition of diethylzinc to cyclic enones

✍ Scribed by Shaohua Gou; Zaher M. A. Judeh

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
131 KB
Volume
23
Category
Article
ISSN
0899-0042

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✦ Synopsis

Abstract

New amino acid‐based modular chiral ligands were readily synthesized and used to catalyze the asymmetric conjugate addition of Et~2~Zn to various cyclic enones in the presence of a variety of copper sources. Moderately high ee of up to 72% were obtained using ligand (S)‐1e under mild conditions. Chirality 2011. Β© 2010 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Modular amino acid amide chiral ligands
Modular amino acid amide chiral ligands for enantioselective addition of diethylzinc to aromatic aldehydes
✍ Shaohua Gou; Zhongbin Ye; Jing Chang; Guangjun Gou; Mingming Feng πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 129 KB πŸ‘ 2 views

## Abstract Enantioselective addition of diethylzinc to a series of aromatic aldehydes was developed using a modular amino acid amide chiral ligand (2__S__)‐3‐phenyl‐__N__‐((__R__)‐1‐phenyl‐ethyl)‐2‐(tosylamino)propanamide without using titanium complex. The catalytic system employing 10 mol% of 1g